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Colon Cancer/ Colorectal Cancer
Colorectal cancer starts either in the large intestine (colon) or in the rectum (end of the colon). The most common form is called adenocarcinoma of the colon. Research shows that most colorectal cancers start as benign polyps, which over a period of many years develop into cancers. Other factors that contribute are ulcerative colitis, a family history of colon cancer and a high-meat, high-fat, low-fiber diet. The National Cancer Institute estimated 148,810 new cases of colon and rectal cancer in 2008.
| Company | Product | Phase | |
| Spectrum Pharmaceuticals Inc | Fusilev with 5-Fluorouracil-based chemotherapy | PA | Colorectal Cancer |
| Genentech Inc | Avastin with Fluorouracil Based Chemotherapy | M | Colorectal Cancer |
| Amgen Inc | Vectibix | M | Colorectal Cancer |
| Genentech, Inc. | Avastin with XELOX or FOLFOX | III | Colorectal Cancer |
| Genentech, Inc. | Xelox | III | Colorectal Cancer |
| Genentech, Inc. | Avastin (Second Line Therapy) | III | Colorectal Cancer |
| Genentech, Inc. | Avastin with Chemotherapy and Tarceva | III | Colorectal Cancer |
| Amgen Inc | Vectibix with FOLFIRI (Second Line Therapy) | III | Colorectal Cancer |
| Amgen Inc | Vectibix with FOLFOX | III | Colorectal Cancer |
| Genomic Health Inc | Colon Cancer Diagnostic | II | Colorectal Cancer |
| Jennerex Biotherapeutics, Inc. | JX594 | II | Colorectal Cancer |
| Genentech Inc | ABT869 | II | Colorectal Cancer |
| Poniard Pharmaceuticals Inc | AMD473 with 5-fluorouracil and Leucovorin (First Line Therapy) | II | Colorectal Cancer |
| Amgen Inc | AMG102 with Panitumumab | II | Colorectal Cancer |
| Amgen Inc | AMG386 with FOLFIRI | II | Colorectal Cancer |
| Amgen Inc | AMG479 with Panitumumab | II | Colorectal Cancer |
| Amgen Inc | AMG655 with mFOLFOX6 and Bevacizumab (First-Line Therapy) | II | Colorectal Cancer |
| Amgen Inc | AMG655 with Panitumumab | II | Colorectal Cancer |
| Actis Biologics, Inc. | Angiozyme | II | Colorectal Cancer |
| Genentech, Inc. | Avastin with Capecitabine and Oxaliplatin (First Line Therapy) | II | Colorectal Cancer |
| Genentech, Inc. | Avastin with RAD001 | II | Colorectal Cancer |
| Genentech, Inc. | Avastin with Tarceva, FOLFOX | II | Colorectal Cancer |
| Genentech, Inc. | Avastin with Xeloda | II | Colorectal Cancer |
| ACT Biotech, Inc. | BAY579352 (Second Line) | II | Colorectal Cancer |
| Genentech, Inc. | GDC0449 with Bevacizumab and Chemotherapy (First Line Therapy) | II | Colorectal Cancer |
| Onyx Pharmaceuticals Inc w/ Bayer Healthcare Pharmaceuticals | Nexavar | II | Colorectal Cancer |
| Onyx Pharmaceuticals Inc | Nexavar with mFOLFOX6 | II | Colorectal Cancer |
| Nektar Therapeutics | NKTR102 | II | Colorectal Cancer |
| Nektar Therapeutics | NKTR102 with Cetuximab (Second Line Therapy) | II | Colorectal Cancer |
| SuperGen Inc | Orathecin | II | Colorectal Cancer |
| HERMES Biosciences | PEP02 with 5-Flourouracil and leucovorin | II | Colorectal Cancer |
| Cytokinetics Inc | SB715992 (Second Line Therapy) | II | Colorectal Cancer |
| Genentech, Inc. | Tarceva with Chemotherapy | II | Colorectal Cancer |
| Genentech, Inc. | Tarceva with Oxaliplatin and Capecitabine | II | Colorectal Cancer |
| Telik Inc | Telcyta | II | Colorectal Cancer |
| Amgen Inc | Vectibix with FOLFIRI (First Line Therapy) | II | Colorectal Cancer |
Esophageal Cancer
Esophageal cancer forms in tissues lining the esophagus, the muscular tube through which food passes from the throat to the stomach. Two types of esophageal cancer are squamous cell carcinoma (cancer that begins in flat cells lining the esophagus) and adenocarcinoma (cancer that begins in cells that make and release mucus and other fluids). Very small tumors in the esophagus usually do not cause symptoms. As a tumor grows, the most common symptom is difficulty in swallowing. The National Cancer Institute estimated 16,470 new cases in 2008.
| Company | Product | Phase | |
| Genentech, Inc. | Avastin with Chemoradiation | II | Esophageal Cancer |
| Genentech, Inc. | Avastin with Modified DCF | II | Esophageal Cancer |
| Genentech, Inc. | Avastin, Tarceva with Chemotherapy, Radiotherapy | II | Esophageal Cancer |
