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Multiple Sclerosis (MS)
Multiple Sclerosis is a chronic disorder in which damage occurs to the protective tissue, known as myelin, surrounding the nerve fibers of the central nervous system. With MS, a person’s immune system malfunctions and starts attacking the body’s own tissues. In this case, the myelin sheaths are affected. Myelin protects the nerves and is necessary for their proper function. As the disease progresses and myelin is destroyed, the nerve impulses are interrupted and the symptoms of MS occur.
The 400,000 Americans with MS are different in the extent to which they are affected. There are four clinical courses of the disease which range from occasional flare ups to the constant worsening of symptoms and combinations of the two.
| Company | Product | Phase | |
| Bayer HealthCare Pharmaceuticals with Novartis | Betaferon / Betaseron (interferon beta- 1b) | M | Multiple Sclerosis |
| Questcor Pharmaceuticals Inc | H.P. Acthar | M | Multiple Sclerosis |
| AutoImmune Inc | MBP8298 | III | Multiple Sclerosis |
| Genentech Inc | Rituxan | III | Multiple Sclerosis |
| Asphelia Pharmaceuticals, Inc. | ASP1002 | II | Multiple Sclerosis |
| Isis Pharmaceuticals Inc | ATL1102 | II | Multiple Sclerosis |
| Bayhill Therapeutics Inc | BHT3009 | II | Multiple Sclerosis |
| MediciNova Inc | MN166 | II | Multiple Sclerosis |
| Genentech Inc | R1594 | II | Multiple Sclerosis |
| Facet Biotech Corporation | Zenapax | II | Multiple Sclerosis |
Myasthenia Gravis
Myasthenia Gravis is a chronic neuromuscular disease that leads to fluctuating weakness and fatigue. The waxing-and-waning weakness of muscles, worsening with use and improving with rest, is a hallmark of this particular disease. Myasthenia gravis is caused by a defect in the transmission of nerve impulses to muscles. It is a lesser known disorder and is estimated to affect about 14 people per 100,000 in the U.S.
| Company | Product | Phase | |
| Valeant Pharmaceuticals International | Mestinon | M | Myasthenia Gravis |
| Valeant Pharmaceuticals International | Prostigmin | M | Myasthenia Gravis |
| Impax Laboratories Inc | Pyridostigmine bromide | M | Myasthenia Gravis |
| Watson Pharmaceuticals Inc | Pyridostigmine bromide | M | Myasthenia Gravis |
| Valeant Pharmaceuticals International | Tensilon | M | Myasthenia Gravis |
Obsessive Compulsive Disorder
Obsessive-compulsive disorder (OCD) is a potentially disabling anxiety disorder. A person who has OCD has intrusive and unwanted thoughts and repeatedly performs tasks to get rid of the thoughts. The effects of OCD range from mild to severe.
| Company | Product | Phase | |
| Jazz Pharmaceuticals | Luvox | M | Obsessive-Compulsive Disorder |
| Jazz Pharmaceuticals | Luvox CR | M | Obsessive-Compulsive Disorder |
