Central Nervous System

The nervous system has two components: the Central Nervous System (CNS) and the Peripheral Nervous System (PNS). The CNS consists of the brain, spinal cord, and optic nerves; all the other nerves in the body makeup the PNS. Nerves allow a person to sense and respond to the stimuli of the external environment. They also control movement. The brain is at the center of this system, receiving and sending the signals that together make up the experience of living.

Alzheimer’s disease

Alzheimer's disease is a progressive condition that affects areas of the brain involved in memory, intelligence, judgment, language and behavior. It is the most common form of dementia in older adults. Alzheimer's disease is more severe than the mild memory loss that many people experience as they grow older. Alzheimer's disease also affects behavior, personality, the ability to think clearly and the ability to carry out daily activities. Close family members usually notice symptoms first, although the person affected also may realize that something is wrong. Scientists think that as many as 4.5 million Americans suffer from AD.

Company Product Phase  
Watson Pharmaceuticals Inc Galantamine hydrobromide M Alzheimer Disease
Neurobiological Technologies Inc Namenda M Alzheimer Disease
Medivation Inc Dimebon III Alzheimer Disease
Voyager Memryte III Alzheimer Disease
Medivation Inc PF1913539 III Alzheimer Disease
Medivation Inc PF1913539 with Donepezil hydrochloride III Alzheimer Disease
Teikoku Pharma USA, Inc. Aricept II Alzheimer Disease
Cortex Pharmaceuticals Inc CX717 II Alzheimer Disease
CoMentis Inc GTS21 II Alzheimer Disease

Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive, invariably fatal neurological disease that attacks the nerve cells (neurons) responsible for controlling voluntary muscles. In ALS, the affected nerves are known as motor neurons, which transfer signals from the brain to the muscles of the body and directing movement. The first symptoms to appear are a general weakness in the arms, legs and in the speaking and breathing muscles. Eventually, these muscles will become weaker and atrophy (wither and become smaller). As many as 20,000 Americans have ALS, and an estimated 5,000 people in the United States are diagnosed with the disease each year.

Company Product Phase  
Impax Laboratories Inc Riluzole M Amyotrophic Lateral Sclerosis
Avicena Group Inc AL02 III Amyotrophic Lateral Sclerosis
CytRx Corporation BRX345 III Amyotrophic Lateral Sclerosis
Avicena Group Inc ALS08 II Amyotrophic Lateral Sclerosis
CytRx Corp Arimoclomol II Amyotrophic Lateral Sclerosis
Sangamo BioSciences Inc SB509 II Amyotrophic Lateral Sclerosis

Anxiety

Anxiety is a combination of emotions including fear, apprehension and worry. Researchers believe that anxiety is the body’s way of preparing for, avoiding and dealing with external threats. There may be cognitive, somatic, emotional and behavioral components, including expectation of danger, high blood pressure, increased heart rate, sweating, inhibited digestive and immune function, trembling and a sense of panic, nausea and chills. According to the National Institute of Mental Health, anxiety disorders affect about 40 million Americans.

Company Product Phase  
Valeant Pharmaceuticals International Anxiron M Anxiety
Valeant Pharmaceuticals International Buspiron M Anxiety
Watson Pharmaceuticals Inc Buspirone hydrochloride M Anxiety
Watson Pharmaceuticals Inc Chlordiazepoxide hydrochloride M Anxiety
Watson Pharmaceuticals Inc Clorazepate dipotassium M Anxiety
Watson Pharmaceuticals Inc Diazepam M Anxiety
Watson Pharmaceuticals Inc Hydroxyzine hydrochloride M Anxiety
Watson Pharmaceuticals Inc Hydroxyzine pamoate M Anxiety
moksha8 Pharmaceuticals Inc Lexotan M Anxiety
Valeant Pharmaceuticals International Librium M Anxiety
Watson Pharmaceuticals Inc Lorazepam M Anxiety
Valeant Pharmaceuticals International Loretam M Anxiety
Jazz Pharmaceuticals Luvox CR M Anxiety
Watson Pharmaceuticals Inc Meprobamate M Anxiety
Valeant Pharmaceuticals International Nitrazepam M Anxiety
Watson Pharmaceuticals Inc Perphenazine, Amitriptyline M Anxiety
Valeant Pharmaceuticals International Remestan M Anxiety
moksha8 Pharmaceuticals Inc Zoloft M Anxiety
Neurocrine Biosciences Inc 876008 II Anxiety
Avineuro Pharmaceuticals, Inc. AVN397 II Anxiety
Neurocrine Biosciences Inc GSK561679 II Anxiety
BrainCells Inc. MKC231 II Anxiety
Pherin Pharmaceuticals Inc PH94B II Anxiety
Impax Laboratories Inc Alprazolam A Anxiety

Attention Deficit Hyperactivity Disorder (ADHD)

It is estimated that one child in a class of 25-30 children suffers from Attention Deficit Hyperactivity Disorder. The disorder usually becomes apparent during the first few years of school and is characterized by two major symptoms: attention deficit (problems paying attention) and hyperactivity (difficulty in controlling behavior). There is little compelling evidence at this time that ADHD can arise purely from social factors or child-rearing methods. Most substantiated causes appear to fall in the realm of neurobiology and genetics.

Company Product Phase  
Impax Laboratories Inc. Amphetamine ER IMPAX PA Attention Deficit Disorder with Hyperactivity
Impax Laboratories Inc. Methylphenidate hydrochloride ER PA Attention Deficit Disorder with Hyperactivity
Impax Laboratories Inc Amphetamine, Dextroamphetamine M Attention Deficit Disorder with Hyperactivity
Watson Pharmaceuticals Inc Amphetamine, Dextroamphetamine M Attention Deficit Disorder with Hyperactivity
Watson Pharmaceuticals Inc Methylphenidate hydrochloride M Attention Deficit Disorder with Hyperactivity
Cortex Pharmaceuticals Inc CX717 II Attention Deficit Disorder with Hyperactivity
CoMentis Inc GTS21 II Attention Deficit Disorder with Hyperactivity
Auriga Laboratories Inc Liquadd A Attention Deficit Disorder with Hyperactivity

Bipolar Disorder

Bipolar Disorder is a medical condition in which people have mood swings out of proportion, or totally unrelated, to things going on in their lives. These swings affect thoughts, feelings, physical health, behavior and functioning. About 5.7 million American adults or about 2.6 percent of the population age 18 and older in any given year, have bipolar disorder according to the National Institute of Mental Health.

Company Product Phase  
Anchen Pharmaceuticals, Inc. Divalproex sodium ER M Bipolar Disorder

Blepharospasm

Blepharospam is the twitching of an eyelid. It is often benign and related to emotional stress, sleep deprivation or the use of stimulants (for example amphetamines, caffeine, nicotine and decongestants).

Company Product Phase  
Allergan Inc Botox M Blepharospasm
Allergan Inc Botox M Hemifacial Spasm

Brain Injuries

Accidents can cause trauma to the brain. Because the brain is the most important organ in the body, it is crucial that everything is done to ensure its continued proper function. Treatments aid the healing of brain tissue without permanent damage.

Company Product Phase  
Oxygen Biotherapeutics Inc Oxycyte II Traumatic Brain Injury
Xytis Inc XY2405 II Traumatic Brain Injury

Cervical Dystonia

Cervical dystonia, also known as spasmodic torticollis, is a focal dystonia characterized by neck muscles that contract involuntarily, causing abnormal movements and posture of the head and neck.

Company Product Phase  
Allergan Inc Botox PM Cervical Dystonia

Dementia

Dementia is an organic mental disorder characterized by a general loss of intellectual abilities involving impairment of memory, judgment and abstract thinking and changes in personality.

Company Product Phase  
Watson Pharmaceuticals Inc Rivastigmine tartrate M Dementia
Adamas Pharmaceuticals, Inc. ADS8703 II Dementia

Depression

Depression, also known as clinical or severe depression, is a state of intense sadness and melancholia that has become disruptive to an individual’s ability to function socially and complete the daily activities of life. Most people feel depressed and “down” at some point in their life; it is when these feelings are prolonged that clinical depression is suspect. According to the World Health Organization, clinical depression is currently the leading cause of disability in the U.S. and is expected to become the leading cause of disability worldwide by the year 2020.

Company Product Phase  
Impax Laboratories Inc. Venlafaxine hydrochloride ER PA Depression
Valeant Pharmaceuticals International Amitriptylinum M Depression
Watson Pharmaceuticals Inc Amoxapine M Depression
Impax Laboratories Inc. Budeprion XL IMPAX M Depression
Watson Pharmaceuticals Inc Bupropion Hcl Z WATSON M Depression
Anchen Pharmaceuticals Inc Bupropion hydrochloride M Depression
Impax Laboratories Inc Bupropion hydrochloride M Depression
Watson Pharmaceuticals Inc Bupropion hydrochloride M Depression
Watson Pharmaceuticals Inc Citalopram hydrobromide M Depression
Valeant Pharmaceuticals International Deprexetin M Depression
Watson Pharmaceuticals Inc Desipramine M Depression
Watson Pharmaceuticals Inc Doxepin hydrochloride M Depression
DEY L.P. Emsam M Depression
Watson Pharmaceuticals Inc Emsam M Depression
Valeant Pharmaceuticals International Fluoxetina M Depression
Watson Pharmaceuticals Inc Fluoxetine M Depression
Valeant Pharmaceuticals International Levate M Depression
Valeant Pharmaceuticals International Limbitrol M Depression
Watson Pharmaceuticals Inc Mirtazapine M Depression
Watson Pharmaceuticals Inc Nefazodone hydrochloride M Depression
Watson Pharmaceuticals Inc Nortriptyline hydrochloride M Depression
Valeant Pharmaceuticals International Norventyl M Depression
Watson Pharmaceuticals Inc Paroxetine hydrochloride M Depression
Impax Laboratories Inc. Pristiq M Depression
Watson Pharmaceuticals Inc Sertraline hydrochloride M Depression
AXM Pharma Inc Tong yang M Depression
Watson Pharmaceuticals Inc Trazodone M Depression
Valeant Pharmaceuticals International Trazorel M Depression
Valeant Pharmaceuticals International Tryptan M Depression
moksha8 Pharmaceuticals Inc Zoloft M Depression
Corcept Therapeutics Inc Corlux III Depression
Neurocrine Biosciences Inc 876008 II Depression
BrainCells Inc BCI540 II Depression
BrainCells Inc. BCI952 II Depression
Neurocrine Biosciences Inc GSK561679 II Depression
BrainCells Inc MKC231 II Depression
Cortex Pharmaceuticals Inc Org26576 II Depression

Emotional Lability

Emotional lability is described as a sudden change in response to events or phrases that others might find only mildly arousing. It causes sudden and unpredictable episodes of crying, laughing or other emotional displays.

Company Product Phase  
AVANIR Pharmaceuticals Zenvia PA Emotional Lability

Epilepsy

Epilepsy occurs as a result of abnormal electrical activity originating from neurons in the brain. Brain cells communicate by sending electrical signals in an orderly pattern. In epilepsy, these electrical signals become abnormal, giving rise to an "electrical storm" that produces seizures. Epilepsy is a relatively common condition in the U.S. and about 2.5 million people have epilepsy. In fact, about 9 percent of Americans will have at least one seizure during their lives.

Company Product Phase  
Impax Laboratories Inc Carbatrol M Epilepsy
Valeant Pharmaceuticals International Clonapam M Epilepsy
Valeant Pharmaceuticals International Diastat M Epilepsy
Valeant Pharmaceuticals International Diastat AcuDial M Epilepsy
Valeant Pharmaceuticals International Dipromal M Epilepsy
Impax Laboratories Inc. Divalproex ER M Epilepsy
Watson Pharmaceuticals Inc Divalproex sodium M Epilepsy
Anchen Pharmaceuticals, Inc. Divalproex sodium ER M Epilepsy
Watson Pharmaceuticals Inc Lorazepam M Epilepsy
Valeant Pharmaceuticals International Mogadon M Epilepsy
Valeant Pharmaceuticals International Mysoline M Epilepsy
moksha8 Pharmaceuticals Inc Neurontin M Epilepsy
PhenobarbitalValeant Pharmaceuticals International M Epilepsy
Impax Laboratories Inc Primidone M Epilepsy
Watson Pharmaceuticals Inc Primidone M Epilepsy
Valeant Pharmaceuticals International Ronton M Epilepsy
Valeant Pharmaceuticals International Sertan M Epilepsy
Valeant Pharmaceuticals International Sevenal M Epilepsy
Valeant Pharmaceuticals International Sevenaletta M Epilepsy
Valeant Pharmaceuticals International Topiramate M Epilepsy
Watson Pharmaceuticals Inc Valproic acid M Epilepsy
Valeant Pharmaceuticals International D23129 III Epilepsy
Valeant Pharmaceuticals International Retigabine III Epilepsy
Jazz Pharmaceuticals JZP8 II Epilepsy

Fibromyalgia Syndrome

Fibromyalgia is a chronic syndrome characterized by specific muscle, joint, or bone pain, fatigue and a large range of other symptoms. There is usually a heightened sensitivity to the skin, tingling of the skin, achiness in the muscles, limb weakness and nerve pain. This condition is seen in 3 percent to 6 percent of the general population and is often diagnosed between the ages of 20 and 50 years old.

Company Product Phase  
Jazz Pharmaceuticals JZP6 III Fibromyalgia Syndrome
Cypress Bioscience Incorporated Savella M Fibromyalgia Syndrome

Hemifacial Spasm – see Blepharospasm

Huntington Disease

Huntington disease is a genetic, progressive, neurodegenerative disorder characterized by the gradual development of involuntary muscle movements affecting the hands, feet, face and trunk and can cause dementia. It is one of the first inherited genetic disorders for which an accurate test exists. Huntington disease affects an estimated 3 to 7 per 100,000 people of European ancestry according to the National Institutes of Health.

Company Product Phase  
Medivation Inc PF1913539 III Huntington Disease
Medivation Inc Dimebon II Huntington Disease
Avicena Group Inc HD-02 II Huntington Disease

Impulse Control Disorders

Disorders whose essential features are the failure to resist an impulse, drive, or temptation to perform an act that is harmful to the individual or to others. Individuals experience an increased sense of tension prior to the act and pleasure, gratification or release of tension at the time of committing the act.

Company Product Phase  
Somaxon Pharmaceuticals Inc Oral Nalmefene III Impulse Control Disorders

Intermittent Claudication

An aching, crampy, tired and sometimes burning pain in the legs that comes and goes- it typically occurs with walking and goes away with rest - due to poor circulation of blood in the arteries of the legs. The usually intermittent nature of the pain is due to narrowing of the arteries that supply the leg with blood, limiting the supply of oxygen to the leg muscles, a limitation that is felt especially when the oxygen requirement of these muscles rises with exercise. Intermittent claudication in and of itself is often a symptom of severe atherosclerotic disease of the peripheral vascular system.

Mania

Mania is a medical condition characterized by extremely elevated mood, energy and unusual thought patterns. There are several possible causes for mania, but it is most often associated with bipolar disorder, where episodes of mania may cyclically alternate with episodes of clinical depression. These cycles may relate to diurnal rhythms and environmental stressors. Mania varies in intensity, from mild mania (known as hypomania) to full-blown mania with psychotic features (hallucinations and delusions).

Company Product Phase  
Valeant Pharmaceuticals International Carbolith M Mania

Memory

Memory is the ability to store, retain and recall information from the brain. The study of memory has become one of the pillars of a new branch of science that marries cognitive psychology and neuroscience. Over time, it may become more difficult for people to remember little things here and there; memory loss is generally associated with old age and is a common symptom of several diseases such as Alzheimer’s, dementia and hypothyroidism.

Company Product Phase  
AXM Pharma Inc Piracetam M Memory Impairment
AXM Pharma Inc Reheal M Memory Impairment
Helicon Therapeutics, Inc. HT0712 II Memory Impairment

Migraine

Migraine headaches are one of the most common and most debilitating neurological conditions characterized by severe pain on one or both sides of the head. They are usually accompanied by sensitivity to light, sound and nausea. It is estimated that migraine headaches are widespread throughout the population, with 10 percent of the population diagnosed and 5 percent undiagnosed. Migraine is three times more common in women than in men.

Company Product Phase  
Zogenix Inc Sumatriptan DosePro PA Migraine
Watson Pharmaceuticals Inc Butalbital, Acetaminophen, Caffeine M Headache
Watson Pharmaceuticals Inc Butalbital, Acetaminophen, Caffeine, codeine phosphate M Headache
Lee Pharmaceuticals Cope M Headache
Victory Pharma Inc Dolgic Plus M Headache
Watson Pharmaceuticals Inc Fioricet M Headache
Watson Pharmaceuticals Inc Fioricet with Codeine M Headache
Watson Pharmaceuticals Inc Fiorinal M Headache
Valeant Pharmaceuticals International Phrenilin M Headache
Allergan Inc Amerge M Migraine
Valeant Pharmaceuticals International D.H.E. 45 M Migraine
Anchen Pharmaceuticals, Inc. Divalproex sodium ER M Migraine
Allergan Inc Imitrex M Migraine
Valeant Pharmaceuticals International Migranal M Migraine
Valeant Pharmaceuticals International Sandomigran M Migraine
Spectrum Pharmaceuticals Inc Sumatriptan Succinate SPECTRUM M Migraine
Allergan Inc Botox III Migraine
MAP Pharmaceuticals Inc Levadex III Migraine
Alexza Pharmaceuticals Inc AZ001 II Migraine
Alexza Pharmaceuticals Inc AZ104 II Migraine
Nektar Therapeutics Dronabinol II Migraine
Capnia, Inc. Nasal Carbon dioxide II Migraine
Roxro Pharma Inc ROX828 II Migraine
Xenoport Inc Solzira II Migraine
TorreyPines Therapeutics Inc Tezampanel II Migraine

Motion Sickness

Motion sickness is induced by motion (as in travel by air, car or ship) and characterized by nausea.

Company Product Phase  
Watson Pharmaceuticals Inc Meclizine hydrochloride M Motion Sickness

Multiple Sclerosis (MS)

Multiple Sclerosis is a chronic disorder in which damage occurs to the protective tissue, known as myelin, surrounding the nerve fibers of the central nervous system. With MS, a person’s immune system malfunctions and starts attacking the body’s own tissues. In this case, the myelin sheaths are affected. Myelin protects the nerves and is necessary for their proper function. As the disease progresses and myelin is destroyed, the nerve impulses are interrupted and the symptoms of MS occur.

The 400,000 Americans with MS are different in the extent to which they are affected. There are four clinical courses of the disease which range from occasional flare ups to the constant worsening of symptoms and combinations of the two.

Company Product Phase  
Bayer HealthCare Pharmaceuticals with Novartis Betaferon / Betaseron (interferon beta- 1b) M Multiple Sclerosis
Questcor Pharmaceuticals Inc H.P. Acthar M Multiple Sclerosis
AutoImmune Inc MBP8298 III Multiple Sclerosis
Genentech Inc Rituxan III Multiple Sclerosis
Asphelia Pharmaceuticals, Inc. ASP1002 II Multiple Sclerosis
Isis Pharmaceuticals Inc ATL1102 II Multiple Sclerosis
Bayhill Therapeutics Inc BHT3009 II Multiple Sclerosis
MediciNova Inc MN166 II Multiple Sclerosis
Genentech Inc R1594 II Multiple Sclerosis
Facet Biotech Corporation Zenapax II Multiple Sclerosis

Myasthenia Gravis

Myasthenia Gravis is a chronic neuromuscular disease that leads to fluctuating weakness and fatigue. The waxing-and-waning weakness of muscles, worsening with use and improving with rest, is a hallmark of this particular disease. Myasthenia gravis is caused by a defect in the transmission of nerve impulses to muscles. It is a lesser known disorder and is estimated to affect about 14 people per 100,000 in the U.S.

Company Product Phase  
Valeant Pharmaceuticals International Mestinon M Myasthenia Gravis
Valeant Pharmaceuticals International Prostigmin M Myasthenia Gravis
Impax Laboratories Inc Pyridostigmine bromide M Myasthenia Gravis
Watson Pharmaceuticals Inc Pyridostigmine bromide M Myasthenia Gravis
Valeant Pharmaceuticals International Tensilon M Myasthenia Gravis

Obsessive Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a potentially disabling anxiety disorder. A person who has OCD has intrusive and unwanted thoughts and repeatedly performs tasks to get rid of the thoughts. The effects of OCD range from mild to severe.

Company Product Phase  
Jazz Pharmaceuticals Luvox M Obsessive-Compulsive Disorder
Jazz Pharmaceuticals Luvox CR M Obsessive-Compulsive Disorder

Pain

Pain can arise for a variety of reasons including injury, post-surgery and a complex malfunction of the nerves. While effective pain management is an important part of the healing process, many people must cope daily with pain caused from other nerve ailments. Keeping pain under control can lead to a more comfortable and thus happier, individual.

Company Product Phase  
NeurogesX, Inc. Qutenza PA Neuralgia
Cadence Pharmaceuticals Inc Acetavance PA Pain
Mentor Corporation Prevelle Plus PA Pain
DURECT Corporation Remoxy PA Pain
Roxro Pharma Inc ROX888 PA Pain
Impax Laboratories Inc. Tramadol hydrochloride ER PA Pain
Watson Pharmaceuticals Inc Blue Gel-WATSON M Muscle Pain
Johnson & Johnson Flexeril (cyclobenzaprine hydrochloride) M Muscle Pain
Watson Pharmaceuticals Inc Baclofen M Muscle Relaxant
Watson Pharmaceuticals Inc Carisoprodol M Muscle Relaxant
Watson Pharmaceuticals Inc Cyclobenzaprine hydrochloride M Muscle Relaxant
Watson Pharmaceuticals Inc Methocarbamol M Muscle Relaxant
Watson Pharmaceuticals Inc Orphenadrine citrate M Muscle Relaxant
Watson Pharmaceuticals Inc Capsaicin M Pain
Impax Laboratories Inc. Carbatrol M Pain
Teikoku Pharma USA Inc Lidoderm M Pain
Watson Pharmaceuticals Inc Aceta-Gesic M Pain
Watson Pharmaceuticals Inc Acetaminophen, codeine phosphate M Pain
Allergan Inc Acular PF M Pain
Watson Pharmaceuticals Inc Anexsia M Pain
Valeant Pharmaceuticals International Artinor M Pain
BIO-VED Pharmaceuticals Inc. Artrex M Pain
Watson Pharmaceuticals Inc Aspirin M Pain
Valeant Pharmaceuticals International Asprocol M Pain
Valeant Pharmaceuticals International Biofenac M Pain
Valeant Pharmaceuticals International Bupren M Pain
Watson Pharmaceuticals Inc Butalbital, Aspirin, Caffeine, Codiene phosphate M Pain
AXM Pharma Inc Camphor, Menthol, Methyl salicylate M Pain
Watson Pharmaceuticals Inc Capsaicin M Pain
Valeant Pharmaceuticals International Cesamet M Pain
PureTek Corporation Circulation stimulator M Pain
AXM Pharma Inc Compound Aspirin M Pain
PureTek Corporation D-Care tired muscle M Pain
Pacira Pharmaceuticals Inc DepoDur M Pain
Lee Pharmaceuticals DeWitt's Pain Reliever M Pain
Novartis AG Diamorphine M Pain
Cymbiotics Inc Diaperin M Pain
Cymbiotics Inc. Diaperin M Pain
Valeant Pharmaceuticals International Dolnot M Pain
Valeant Pharmaceuticals International Dolofast M Pain
Valeant Pharmaceuticals International Dolomax M Pain
BioPro Pharmaceutical Inc Fentanyl M Pain
Watson Pharmaceuticals Inc Fentanyl M Pain
Teikoku Pharma USA Inc Flector EP M Pain
Teikoku Pharma USA, Inc. Flector EP Tissugel M Pain
Cymbiotics Inc Flexasur M Pain
Valeant Pharmaceuticals International Flupirtine M Pain
Teikoku Pharma USA Inc Harrix Gel Pad M Pain
Teikoku Pharma USA, Inc. Harrix Gel Pad M Pain
Valeant Pharmaceuticals International Hydrocodin M Pain
Watson Pharmaceuticals Inc Hydrocodone bitartrate, Acetaminophen M Pain
Watson Pharmaceuticals Inc Hydrocodone/Apap M Pain
Watson Pharmaceuticals Inc Ibuprofen M Pain
Imagenetix Inc Inflameaway Celadrin M Pain
Lee Pharmaceuticals Iodex with Methyl salicylate M Pain
Shaklee Corp Joint and Muscle pain cream and solution M Pain
Valeant Pharmaceuticals International Ketopharm M Pain
Valeant Pharmaceuticals International Ketorolac M Pain
Valeant Pharmaceuticals International Levedad M Pain
Valeant Pharmaceuticals International Levodromoran M Pain
Valeant Pharmaceuticals International M.O.S M Pain
Valeant Pharmaceuticals International M.O.S concentrate M Pain
Valeant Pharmaceuticals International M.O.S sulfate M Pain
Valeant Pharmaceuticals International M.O.S-SR M Pain
Watson Pharmaceuticals Inc Maxidone M Pain
Watson Pharmaceuticals Inc Meperidine hydrochloride M Pain
Valeant Pharmaceuticals International Metanor M Pain
Valeant Pharmaceuticals International Metindol M Pain
Valeant Pharmaceuticals International Midol M Pain
Valeant Pharmaceuticals International Moretal M Pain
Watson Pharmaceuticals Inc Morphine sulfate CR M Pain
Watson Pharmaceuticals Inc Morphine sulfate ER M Pain
moksha8 Pharmaceuticals Inc Motrin M Pain
Santarus Inc Naprelan M Pain
Victory Pharma Inc Naprelan M Pain
Valeant Pharmaceuticals International Naprosyn M Pain
Valeant Pharmaceuticals International Napsyn M Pain
moksha8 Pharmaceuticals Inc Neurontin M Pain
Vitane Pharmaceuticals Inc. No Pain M Pain
Watson Pharmaceuticals Inc Norco M Pain
Lee Pharmaceuticals Norwich M Pain
Valeant Pharmaceuticals International Opana M Pain
Valeant Pharmaceuticals International Opana ER M Pain
Lee Pharmaceuticals OraStat M Pain
Lee Pharmaceuticals OraStat M Pain
Valeant Pharmaceuticals International Otinum M Pain
Watson Pharmaceuticals Inc Oxycodone hydrochloride, Ibuprofen M Pain
Watson Pharmaceuticals Inc Oxycodone, Acetaminophen M Pain
Watson Pharmaceuticals Inc Oxycodone, Aspirin M Pain
Lee Pharmaceuticals P-A-C M Pain
Watson Pharmaceuticals Inc Pentazocine, Naloxone hydrochloride M Pain
Watson Pharmaceuticals Inc Pentazocine-APAP M Pain
Watson Pharmaceuticals Inc Phenaseptic Throat Spray M Pain
Watson Pharmaceuticals Inc Propoxyphene hydrochloride, Acetaminophen M Pain
Valeant Pharmaceuticals International Sachol M Pain
Lee Pharmaceuticals Sloan's Liniment M Pain
Watson Pharmaceuticals Inc Sulindac M Pain
Valeant Pharmaceuticals International Tepilta M Pain
Watson Pharmaceuticals Inc Tramadol hydrochloride M Pain
Valeant Pharmaceuticals International Tricodein M Pain
Lee Pharmaceuticals Tronolane M Pain
Lee Pharmaceuticals Unguentine M Pain
Lee Pharmaceuticals Unguentine Maximum Strength M Pain
Valeant Pharmaceuticals International Vantal M Pain
Teikoku Pharma USA Inc WellPatch M Pain
Victory Pharma Inc Xodol M Pain
Depomed Inc DM1796 III Neuralgia
Depomed Inc Gabapentin GR III Neuralgia
NeurogesX Inc Transacin III Neuralgia
Anesiva Inc Adlea III Pain
Cerimon Pharmaceuticals Inc Diclofenac III Pain
Pacira Pharmaceuticals, Inc. Exparel III Pain
Horizon Therapeutics Inc HZT501 III Pain
Transdel Pharmaceuticals Inc Ketotransdel III Pain
Pain Therapeutics Inc OxyTrex III Pain
Pain Therapeutics Inc Remoxy III Pain
Genentech, Inc. RN624 III Pain
AVANIR Pharmaceuticals Zenvia III Pain
Anesiva Inc Adlea II Muscle Pain
DURECT Corp Eladur II Neuralgia
Epiphany Biosciences, Inc. EPB348 II Neuralgia
Xenoport Inc Solzira II Neuralgia
Anesiva Inc Adlea II Neuropathy
Avigen Inc AV411 II Neuropathy
Xenoport Inc XP13512 II Neuropathy
Allergan Inc AGN203818 II Pain
Allergan Inc AGNXX II Pain
ACADIA Pharmaceuticals Inc AGN-XX II Pain
Allergan Inc AGNYY II Pain
ACADIA Pharmaceuticals Inc AGN-YY II Pain
AP Pharma Inc APF112 II Pain
AcelRx Pharmaceuticals, Inc. ARX01 II Pain
AcelRx Pharmaceuticals, Inc. ARX02 II Pain
Teikoku Pharma USA Inc Back pain hydrogel patch II Pain
Valeant Pharmaceuticals International D23129 II Pain
Pacira Pharmaceuticals, Inc. Exparel II Pain
KAI Pharmaceuticals Inc. KAI1678 II Pain
Kalypsys Inc KD7040 II Pain
Kadmus Pharmaceuticals KDS-2000 II Pain
Victory Pharma Inc MGX001 II Pain
DURECT Corp Posidur II Pain
Teikoku Pharma USA Inc Post-op-pain II Pain
DURECT Corp TRANSDUR II Pain
DURECT Corporation TRANSDUR-Sufentanil II Pain
Zogenix Inc ZX002 II Pain
NeurogesX, Inc. Qutenza A Neuropathy
Allergan Inc Acuvail A Pain
Novalar Pharmaceuticals Inc OraVerse A Pain
Impax Laboratories Inc Oxymorphone hydrochloride A Pain
Anesiva Inc Zingo (lidocaine hydrochloride) A Pain

Panic Disorders

A panic attack is an episode of intense fear or psychological distress which suddenly appears and symptoms include trembling, shortness of breath, heart palpitations, sweating, nausea, dizziness, hyperventilation and sensations of choking. Repeated attacks may be a sign of a panic disorder and are usually associated with other anxiety problems. It is estimated that up to 10 percent of people in the U.S. will experience a panic disorder at some point in their lives.

Company Product Phase  
Watson Pharmaceuticals Inc Clonazepam M Panic Disorder
Alexza Pharmaceuticals Inc AZ002 II Panic Disorder

Parkinson Disease

Parkinson's disease is a disorder that affects nerve cells, or neurons, in a part of the brain that controls muscle movement. In Parkinson's, neurons that make a chemical called dopamine die or do not work properly. Dopamine normally sends signals that help coordinate a person’s movements. No one knows what damages these cells. This disease affects 1.5 million in the U.S. and may progress for years.

Company Product Phase  
Watson Pharmaceuticals Inc Eldepryl M Parkinson Disease
Watson Pharmaceuticals Inc Selegiline M Parkinson Disease
Valeant Pharmaceuticals International Selgres M Parkinson Disease
Valeant Pharmaceuticals International Symmetrel M Parkinson Disease
Valeant Pharmaceuticals International Tasmar M Parkinson Disease
Watson Pharmaceuticals Inc Trihexyphenidyl hydrochloride M Parkinson Disease
Valeant Pharmaceuticals International Zelapar M Parkinson Disease
Adamas Pharmaceuticals, Inc. ADS5101 III Parkinson Disease
Impax Laboratories Inc Carbidopa, Levodopa ER III Parkinson Disease
Impax Laboratories Inc. IPX066 III Parkinson Disease
Avicena Group Inc PD02 III Parkinson Disease
ACADIA Pharmaceuticals Inc Pimavanserin III Parkinson Disease
Ceregene Inc CERE120 II Parkinson Disease
Titan Pharmaceuticals Inc Spheramine II Parkinson Disease
Xenoport Inc XP21279 with Lodosyn and Sinemet II Parkinson Disease

Restless Leg Syndrome (RLS)

Restless legs syndrome (RLS) is a disorder that causes a strong urge to move your legs. This urge to move often occurs with strange and unpleasant feelings in your legs. Moving your legs relieves the urge and the unpleasant feelings. People who have RLS describe the unpleasant feelings as creeping, crawling, pulling, itching, tingling, burning, aching, or electric shocks. Sometimes, the feelings also occur in the arms. The urge to move and unpleasant feelings occur when you’re resting and inactive. They tend to be worse in the evening and at night and are temporarily relieved in the morning. Restless legs syndrome (RLS) may affect as many as 12 million people in the United States.

Company Product Phase  
Xenoport Inc Solzira PA Restless Leg Syndrome
Jazz Pharmaceuticals JZP7 II Restless Leg Syndrome

Schizophrenia

Schizophrenia is a serious brain disorder that distorts the way a person thinks, acts, expresses emotions, perceives reality and relates to others. Schizophrenia can leave its sufferer frightened and withdrawn. It is a life-long disease that cannot be cured, but usually can be controlled with proper treatment. Contrary to popular belief, schizophrenia is not a split personality. Schizophrenia is a psychosis, a type of mental illness in which a person cannot tell what is real from what is imagined. Schizophrenia affects about 1.1 percent of the U.S. population age 18 and older in a given year.

Company Product Phase  
Valeant Pharmaceuticals International Depral M Schizophrenia
Leiner Health Products Fiapta (iloperidone) M Schizophrenia
Watson Pharmaceuticals Inc Loxapine M Schizophrenia
Watson Pharmaceuticals Inc Loxitane M Schizophrenia
Valeant Pharmaceuticals International Mellaril M Schizophrenia
Valeant Pharmaceuticals International Mellaril M Schizophrenia
Alexza Pharmaceuticals Inc AZ004 III Schizophrenia
ACADIA Pharmaceuticals Inc ACP-103 (pimavanserin tartrate) II Schizophrenia
Avineuro Pharmaceuticals, Inc. AVN211 II Schizophrenia
Cortex Pharmaceuticals Inc Org24448 II Schizophrenia
Jazz Pharmaceuticals Sodium oxybate II Schizophrenia
Titan Pharmaceuticals Inc Fanapt A Schizophrenia

Seizures

Seizures are a sudden, violent involuntary contraction of a group of muscles that may be paroxysmal and episodical or transient and acute.

Sleep Disorders

Sleep disorders include sleeping too much or a lack there of. Doctors recommend eight to ten hours of sleep a night; the average American only gets seven. Insomnia is defined as the inability to sleep and/or to be incapable of remaining asleep for any lengthy amount of time. A common complaint amongst insomniacs is the inability to “turn off their mind” for more than just a few minutes at a time. Narcolepsy is a neurological condition characterized by excessive daytime sleep and the disorder of rapid eye movement (REM). It is easily distinguishable, as patients feel overwhelmingly sleepy during the day, even after a full nights’ rest and often tend to fall asleep without warning at inappropriate times and places.

Company Product Phase  
Transcept Pharmaceuticals Inc Intermezzo PA Insomnia
Somaxon Pharmaceuticals Inc Silenor (doxepin hydrochloride) PA Insomnia
Valeant Pharmaceuticals International Benedorm M Insomnia
Allergy Research Group Inc (ALRG) Chronoset Melatonin M Insomnia
Valeant Pharmaceuticals International Dalmadorm M Insomnia
Questcor Pharmaceuticals Inc Doral M Insomnia
Valeant Pharmaceuticals International Edluar M Insomnia
Watson Pharmaceuticals Inc Estazolam M Insomnia
Valeant Pharmaceuticals International Imovane M Insomnia
Valeant Pharmaceuticals International Loramet M Insomnia
Watson Pharmaceuticals Inc Melatonin M Insomnia
Valeant Pharmaceuticals International Normison M Insomnia
Valeant Pharmaceuticals International Sublinox M Insomnia
Allergy Research Group, Inc. Time Release Melatonin M Insomnia
Jazz Pharmaceuticals Xyrem M Narcolepsy
Valeant Pharmaceuticals International Xyrem M Narcolepsy
Watson Pharmaceuticals Inc Desmopressin Acetate WATSON M Nocturnal Enuresis
Valeant Pharmaceuticals International Mogadon M Sleep Disorders
ACADIA Pharmaceuticals Inc ACP-103 (pimavanserin tartrate) II Insomnia
Cortex Pharmaceuticals Inc CX717 II Sleep Disorders
Victory Pharma, Inc. Modafinil combination II Sleep Disorders
Neurocrine Biosciences Inc Indiplon Immediate Release Capsule A Insomnia

Spasticity

Spasticity is a muscle control disorder that is characterized by tight or stiff muscles and an inability to control those muscles. In addition, reflexes may persist for too long and may be too strong (hyperactive reflexes). Caused by an imbalance of signals from the central nervous system to the muscles, spasticity is often found in people with cerebral palsy, traumatic brain injury, stroke, multiple sclerosis and spinal cord injury.

Stress

Stress is an emotional and physical response to threats from the outside world. Common stress reactions include muscular tension, irritability, inability to concentrate, and a variety of physical symptoms, such as headaches and an accelerated heart rate. Stress releases powerful neurochemicals and hormones that prepare us for action (to fight or to flee). If no action is taken, the stress response can lead to health problems. Prolonged, uninterrupted, unexpected and unmanageable stresses are the most damaging types of stress.

West Syndrome

West syndrome, also known as infantile spasm, is a rare serious form of epilepsy in infants. The syndrome is age-related and generally occurs between the third and sixth month, though it is often caused by an organic brain dysfunction whose origins are prenatal, perinatal or postnatal. Scientific research estimates that prevalence is around one in 4,000 to one in 6,000 with boys more likely to be affected than girls. Unfortunately, up to 90 percent of affected children suffer severe physical and cognitive impairments which stay with them throughout their lives.

Company Product Phase  
Questcor Pharmaceuticals Inc H.P. Acthar PA West Syndrome


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