Digestive System

The digestive tract, also known as the gastrointestinal (GI) tract is the system of organs that takes in food, digests it to extract the necessary nutrients and ingredients, and expels the remaining waste. The entire process is known as digestion. In a normal adult male, the GI tract is approximately 25 feet long. Food enters our body through our mouth where it is chewed up and digestive enzymes in our saliva begin to break it down. Once we swallow, the food moves through the esophagus into the stomach where it is further digested by acids and enzymes. The food then goes into the small and large intestines where nutrients are extracted and exported into the bloodstream for transfer to cells throughout the body. Eventually, after most nutritive quality has been taken out, the resulting waste is expelled through the rectum.

Acidity

Acidity is the condition of containing more than the normal amount of acid in the digestive system.

Company Product Phase  
Valeant Pharmaceuticals International Actal M Acidity
Watson Pharmaceuticals Inc Alenic Alka M Acidity
Watson Pharmaceuticals Inc Almacone M Acidity
Watson Pharmaceuticals Inc Aluminum hydroxide M Acidity
Watson Pharmaceuticals Inc Cal-gest M Acidity
AXM Pharma Inc Cascara, Bismuth subnitrate, Magnesium carbonate M Acidity
Lee Pharmaceuticals Citrocarbonate M Acidity
Watson Pharmaceuticals Inc Lowsium Plus M Acidity
Watson Pharmaceuticals Inc Sodium bicarbonate M Acidity

Constipation

Constipation occurs when bowel movements become difficult or less frequent. The normal length of time between bowel movements ranges widely from person to person. Some people have bowel movements three times a day; others, only one or two times a week. Constipation is a symptom, not a disease. Almost everyone experiences constipation at some point in their life, and a poor diet typically is the cause. Most constipation is temporary and not serious. Understanding its causes, prevention, and treatment will help most people find relief. More than 4 million Americans have frequent constipation, accounting for 2.5 million physician visits a year.

Company Product Phase  
Valeant Pharmaceuticals International Bisacodyl M Constipation
Lee Pharmaceuticals Black Draught M Constipation
Watson Pharmaceuticals Inc Diocto M Constipation
Watson Pharmaceuticals Inc Docusate calcium M Constipation
Watson Pharmaceuticals Inc Docusate sodium M Constipation
Watson Pharmaceuticals Inc Enema Disposable M Constipation
Lee Pharmaceuticals Evac-u-gen M Constipation
Valeant Pharmaceuticals International Fenolax M Constipation
Watson Pharmaceuticals Inc Fiber-Lax Polycarbophil M Constipation
Watson Pharmaceuticals Inc Lactulose M Constipation
Watson Pharmaceuticals Inc Laxative EC M Constipation
Watson Pharmaceuticals Inc Milk of Magnesia M Constipation
Valeant Pharmaceuticals International Regulact M Constipation
Watson Pharmaceuticals Inc Reguloid M Constipation
Watson Pharmaceuticals Inc Reguloid S-free M Constipation
Watson Pharmaceuticals Inc Senexon Liquid M Constipation
Watson Pharmaceuticals Inc Stool Softener DC M Constipation
Nektar Therapeutics NKTR118 II Constipation
Theravance Inc TD5108 II Constipation

Diarrhea

Diarrhea is loose, watery stools. It is very common and usually not serious. Many people will have diarrhea once or twice each year. Diarrhea can cause dehydration, which means the body lacks enough fluid to function properly. Dehydration is particularly dangerous in children and older people, and it must be treated promptly to avoid serious health problems.

Company Product Phase  
AXM Pharma Inc Berberine hydrochloride M Diarrhea
Novartis AG Dukoral M Diarrhea
Amdl Inc Furazolidone M Diarrhea
Watson Pharmaceuticals Inc K-Pek II M Diarrhea
Valeant Pharmaceuticals International Loperamide M Diarrhea
Valeant Pharmaceuticals International Lopercap M Diarrhea
Valeant Pharmaceuticals International Motofen M Diarrhea
Watson Pharmaceuticals Inc Oralyte solution M Diarrhea
Watson Pharmaceuticals Inc Peptic Relief M Diarrhea
Osel Inc Cdactin-O III Diarrhea
Napo Pharmaceuticals Inc CRO-HIV III Diarrhea
Optimer Pharmaceuticals, Inc. NM441 III Diarrhea
Napo Pharmaceuticals Inc CRO-IBS II Diarrhea
Napo Pharmaceuticals Inc CRO-ID II Diarrhea
Santarus Inc Rifamycin SV MMX II Diarrhea

Dry Mouth

Saliva moistens and cleanses the mouths and aids in digesting food. Saliva also prevents infection by controlling bacteria and fungi in the mouth. Dry mouth can cause speech and eating difficulties, halitosis (bad breath), an increase in the number of cavities and increased vulnerability to infection. Drug side effects, medication, alcohol trauma, dehydration, radiation therapy and marijuana also may contribute to the problem.

Company Product Phase  
Auriga Laboratories Inc Aquoral M Dry Mouth
Parnell Pharmaceuticals Inc MouthKote M Dry Mouth
Parnell Pharmaceuticals, Inc. MouthKote M Dry Mouth
Impax Laboratories Inc Pilocarpine hydrochlorine M Dry Mouth

Flatulence

Flatulence is the presence of a mixture of gases in the digestive tract of mammals. Intestinal gas is composed of varying quantities of exogenous sources (air that is ingested through the nose and mouth) and endogenous sources (gas produced within the digestive tract). The exogenous gases are swallowed when eating or drinking or increased swallowing during times of excessive salivation. The endogenous gases are produced either as a by-product of digesting certain types of food or of incomplete digestion. Anything that causes food to be incompletely digested by the stomach and/or small intestine may cause flatulence when the material arrives in the large intestine due to fermentation by yeast or bacteria normally or abnormally present in the gastrointestinal tract.

Company Product Phase  
Valeant Pharmaceuticals International Carbotural M Flatulence
Vitane Pharmaceuticals Inc. ColicEZ M Flatulence
Valeant Pharmaceuticals International Disflatyl M Flatulence
Valeant Pharmaceuticals International Espaven M Flatulence
Watson Pharmaceuticals Inc Simethicone Gas Relief M Flatulence

Gallstones

Gallstones are small, pebble-like substances that develop in the gallbladder. The gallbladder is a small, pear-shaped sac located below your liver in the right upper abdomen. Gallstones form when liquid stored in the gallbladder hardens into pieces of stone-like material. The liquid—called bile—helps the body digest fats. Bile is made in the liver, then stored in the gallbladder until the body needs it. The gallbladder contracts and pushes the bile into a tube—called the common bile duct—that carries it to the small intestine, where it helps with digestion. The two types of gallstones are cholesterol stones and pigment stones. Cholesterol stones are usually yellow-green and are made primarily of hardened cholesterol. They account for about 80 percent of gallstones. Pigment stones are small, dark stones made of bilirubin. Gallstones can be as small as a grain of sand or as large as a golf ball. The gallbladder can develop just one large stone, hundreds of tiny stones, or a combination of the two.

Company Product Phase  
Watson Pharmaceuticals Inc Actigall M Gallstones
Valeant Pharmaceuticals International Ursopol M Gallstones

Gastroesophageal Reflux Disease (GERD)

Gastroesophageal reflux disease, known as GERD, is defined as chronic symptoms or mucosal damage produced by the abnormal reflux of gastric (stomach) contents into the esophagus. It is characterized by heartburn, esophageal inflammation, difficulty swallowing and chronic chest pain. Certain foods are known to exacerbate GERD: coffee, alcohol, Vitamin C, high fat foods, soft drinks, chocolate, peppermint and spicy foods, among many others. Patients should first change the foods they eat and ensure that they are exercising regularly. In more serious cases, drug therapies and surgery might be necessary.

Company Product Phase  
Santarus Inc Zegerid PA Gastroesophageal Reflux Disease
Watson Pharmaceuticals Inc Metoclopramide Hydrochloride M Gastroesophageal Reflux Disease
Impax Laboratories Inc Omeprazole M Gastroesophageal Reflux Disease
Watson Pharmaceuticals Inc Omeprazole M Gastroesophageal Reflux Disease
Watson Pharmaceuticals Inc Rulox Plus M Gastroesophageal Reflux Disease
Watson Pharmaceuticals Inc Sodium bicarbonate M Gastroesophageal Reflux Disease
Watson Pharmaceuticals Inc Papaya Enzyme M Gastroesophageal Reflux Disease
Ocera Therapeutics Inc AST120 II Gastroesophageal Reflux Disease
Depomed Inc DM3458 II Gastroesophageal Reflux Disease
Xenoport Inc XP19986 II Gastroesophageal Reflux Disease

Hemorrhoids

The term hemorrhoids refers to a condition in which the veins around the anus or lower rectum are swollen and inflamed. Hemorrhoids may result from straining to move stool. Other contributing factors include pregnancy, aging, chronic constipation or diarrhea, and anal intercourse. Hemorrhoids are either inside the anus—internal—or under the skin around the anus—external. Hemorrhoids are common in both men and women. About half of the population has hemorrhoids by age 50.

Company Product Phase  
Watson Pharmaceuticals Inc Hemorrhoidal suppositories M Hemorrhoids
Lee Pharmaceuticals Medicone M Hemorrhoids

Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a functional bowel disorder characterized by abdominal pain and changes in bowel habits which are not associated with any abnormalities seen on routine clinical testing. Lower abdominal pain, bloating associated with alteration of bowel habits and abdominal discomfort relieved with defecation are the most frequent symptoms. As many as 20 percent of the adult population, or one in five Americans, have symptoms of IBS, making it one of the most common disorders diagnosed by doctors. It occurs more often in women than in men, and it begins before the age of 35 in about 50 percent of people.

Company Product Phase  
Watson Pharmaceuticals Inc Dicyclomine hydrochloride M Irritable Bowel Syndrome
Valeant Pharmaceuticals International Formulex M Irritable Bowel Syndrome
Prometheus Laboratories, Inc. Lotronex M Irritable Bowel Syndrome
Neurocrine Biosciences Inc 876008 II Irritable Bowel Syndrome
Tioga Pharmaceuticals Inc Asimadoline II Irritable Bowel Syndrome

Nausea

Nausea is an unpleasant sensation, vaguely referred to the epigastrium and abdomen and often culminating in vomiting.

Company Product Phase  
Victory Pharma Inc MGX006 PA Nausea and Vomiting
Watson Pharmaceuticals Inc Dimenhydrinate M Nausea and Vomiting
Domperidone Amdl Inc M Nausea and Vomiting
Valeant Pharmaceuticals International Gastrosil M Nausea and Vomiting
Watson Pharmaceuticals Inc Kalmz M Nausea and Vomiting
Valeant Pharmaceuticals International Maxolon M Nausea and Vomiting
Watson Pharmaceuticals Inc Promethazine hydrochloride M Nausea and Vomiting

Pancreatic Diseases

The pancreas is an organ which aids in digestion by producing digestive enzymes that will be used in the stomach and by digestive organelles. The pancreas is also responsible for the production of insulin, the body’s main regulator of sugar in the blood. Because of the large range of functions, there are many diseases and disorders which can be linked to the pancreas. Treatments are being developed to treat pancreatic abnormalities and diseases.

Company Product Phase  
Impax Laboratories Inc Lipram M Pancreatic Diseases

Peptic Ulcer

A peptic ulcer is a sore in the lining of the stomach or duodenum.* The duodenum is the first part of the small intestine. If peptic ulcers are found in the stomach, they're called gastric ulcers. If they're found in the duodenum, they're called duodenal ulcers. A person can have more than one ulcer.

Company Product Phase  
Watson Pharmaceuticals Inc Nizatidine M Duodenal Ulcer
Watson Pharmaceuticals Inc Ranitidine M Duodenal Ulcer
Watson Pharmaceuticals Inc Sucralfate M Duodenal Ulcer
Valeant Pharmaceuticals International Motidin M Gastric Ulcer
Valeant Pharmaceuticals International Libraxin M Peptic Ulcer
Watson Pharmaceuticals Inc Chlordiazepoxide, Clidinium M Ulcers
Valeant Pharmaceuticals International Nuclosina M Ulcers
Watson Pharmaceuticals Inc Omeprazole M Ulcers
Valeant Pharmaceuticals International Ranuber M Ulcers
Valeant Pharmaceuticals International Solvertyl M Ulcers
Valeant Pharmaceuticals International Tisacid M Ulcers
Cogentus Pharmaceuticals CGT2168 III Ulcers

Postoperative Ileus

Postoperative Ileus is a temporary paralysis of a portion of the intestines typically after an abdominal surgery. Since the intestinal content of this portion is unable to move forward, food or drink should be avoided until peristaltic sound is heard from auscultation of the area where this portion lies.

Company Product Phase  
Tioga Pharmaceuticals Inc Asimadoline II Postoperative Ileus

Ulcerative Colitis

Ulcerative colitis is a disease that causes inflammation and sores, called ulcers, in the lining of the rectum and colon. Ulcers form where inflammation has killed the cells that usually line the colon, then bleed and produce pus. Inflammation in the colon also causes the colon to empty frequently, causing diarrhea. When the inflammation occurs in the rectum and lower part of the colon it is called ulcerative proctitis. If the entire colon is affected it is called pancolitis. If only the left side of the colon is affected it is called limited or distal colitis. Ulcerative colitis can occur in people of any age, but it usually starts between the ages of 15 and 30, and less frequently between 50 and 70 years of age. It affects men and women equally and appears to run in families.

Company Product Phase  
Watson Pharmaceuticals Inc Balsalazide sodium M Ulcerative Colitis
Valeant Pharmaceuticals International Hycort M Ulcerative Colitis
Watson Pharmaceuticals Inc Sulfasalazine M Ulcerative Colitis
China Sky One Medical Inc Sulfasalazine M Ulcerative Colitis
Santarus Inc Budesonide MMX III Ulcerative Colitis
Genentech, Inc. MLN0002 III Ulcerative Colitis
Isis Pharmaceuticals Inc Alicaforsen II Ulcerative Colitis
Amalyte Pharmaceuticals, LLC AM3301 II Ulcerative Colitis
Ocera Therapeutics Inc AST120 II Ulcerative Colitis
Prometheus Laboratories Inc Colal-Pred II Ulcerative Colitis
Isis Pharmaceuticals Inc ISIS2302 II Ulcerative Colitis
Cerimon Pharmaceuticals Inc Simulect II Ulcerative Colitis
ChemoCentryx Inc Traficet-EN II Ulcerative Colitis
Hollis-Eden Pharmaceuticals Inc Triolex II Ulcerative Colitis


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