Substance Abuse

Many addictions have long-lasting, life-destroying effects. There are treatments available and under development to help individuals to free themselves from these dependencies, intoxications and addictions.

Alcoholism

Alcoholism is a disorder characterized by pathological pattern of alcohol use that causes a serious impairment in social or occupational functioning

Company Product Phase  
Somaxon Pharmaceuticals Inc Soberal III Alcoholism

Ethylene Glycol Poisoning

Ethylene glycol is an alcohol mainly used as automotive antifreeze. In a pure form, it is odorless, colorless and syrupy in consistency, with a sweet taste. It is toxic and accidental ingestion is considered a medical emergency. Because of its sweet taste, children and animals will sometimes consume large quantities of the liquid. Symptoms of poisoning include dizziness, slurred speech and confusion followed by heartbeat and breathing irregularities. This eventually may lead to kidney failure.

Methanol Poisoning

Methanol is a sweet alcohol which is often used as an antifreeze, solvent, fuel and denaturant for ethyl alcohol. It becomes toxic as the liver breaks it down into formaldehyde, which causes destruction of the optic nerve and blindness. Poisoning can also be fatal due to its depressant properties. Methanol can enter the body by ingestion, inhalation or absorption. Symptoms include depression, headache, dizziness, nausea, confusion, unconsciousness and eventually death. It takes, however, several hours for toxic effects to begin so medical treatment should be sought immediately to receive an antidote.

Narcotic Addiction

Drug addiction is considered a pathological state. The disorder of addiction involves the progression of acute drug use to the development of drug-seeking behavior, the vulnerability to relapse and the decreased, slowed ability to respond to naturally rewarding stimuli. By definition, drug addiction differs from drug dependence and drug tolerance.

Opium Addiction

Opium is a narcotic derived from the unripe seed of the opium poppy. It is usually smoked or ingested and produces general sedative, painkilling effects. Opium derivatives are pharmacologicallly used as strong pain killers, such as in cancer therapy. Opium has been used since the time of the Assyrians and was brought to Europe in the early 17th century by Asian traders along the Silk Road. It has since been banned in most parts of the world, though it is still illegally cultivated around the world in places like Afghanistan. Interestingly enough, opium poppies are often grown for their beautiful flowers and the seeds are dried out and often sweetened for use on breads and pastries.

Company Product Phase  
Amphastar Pharmaceuticals Inc Naloxone hydrochloride M Narcotic Addiction
Titan Pharmaceuticals Inc Probuphine III Opium Addiction
Avigen Inc AV411 II Opium Addiction

Phencyclidine abuse

PCP or Phencyclidine, is a single drug that forms a distinct category of its own because the effects it produces are unlike those of any category. The formal chemical name for this drug is Phenyl Cyclohexyl Piperidine, from which the initials PCP are derived. PCP was first developed as an anesthetic for humans in 1959. Its use was discontinued a few years later due to its extreme side effects which included delirium and confusion. In the early 1960's PCP was brought back to medical use as a veterinary anesthetic under the trade name Sernylan. Among PCP's least desirable side effects are delirium, visual disturbances and hallucinations and, occasionally, violence. Some evidence of long term memory disorders and psychological disturbances resembling schizophrenia has also been linked to PCP.

Poisoning

Accidentally or intentionally, poisoning oneself by taking a substance is injurious to health and can cause death. Poisoning is still a major hazard to children despite child-resistant packaging and dose-limits per container.

Company Product Phase  
DEY LP Cyanokit M Poisoning
Valeant Pharmaceuticals International Carbo medicinalis M Poisoning
BioPro Pharmaceutical, Inc. Savene M Antidote

Smoking Cessation

The chemical compound nicotine, found in tobacco, is highly addictive and once a person begins smoking cigarettes they cannot stop and often continue the unhealthy habit for years. Not only is the nicotine unhealthy, the tar from the cigarettes gets stuck in the lungs, building up over the years and often leads to lung cancer. Additionally, inhaling massive quantities of smoke negatively affects the mouth, throat and lungs. Many long-time smokers will develop some form of cancer in their lifetime. Because of the many harmful effects of smoking cigarettes, it is imperative that smoking cease as soon as possible. Unfortunately, this is usually quite difficult due to the addictive properties of nicotine and requires devotion and perseverance. Many treatments and therapies exist to help smokers quit their habit.

Company Product Phase  
Impax Laboratories Inc Bupropion hydrochloride M Smoking Cessation
Watson Pharmaceuticals Inc Bupropion hydrochloride M Smoking Cessation
Watson Pharmaceuticals Inc Nicotine polacrilex M Smoking Cessation
Watson Pharmaceuticals Inc Nicotine transdermal system M Smoking Cessation
Somaxon Pharmaceuticals Inc Oral Nalmefene II Smoking Cessation


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